Fra-1 replaces c-Fos-dependent functions in mice
نویسندگان
چکیده
منابع مشابه
Fra-1 replaces c-Fos-dependent functions in mice.
Structure-function analysis as well as studies with knock-out and transgenic mice have assigned distinct functions to c-Fos and Fra-1, two components of the transcription factor AP-1 (activator protein-1). To test whether Fra-1 could substitute for c-Fos, we generated knock-in mice that express Fra-1 in place of c-Fos. Fra-1 rescues c-Fos-dependent functions such as bone development and light-i...
متن کاملRestraint-induced fra-2 and c-fos expression in the rat forebrain: relationship to stress duration.
The protein product of the fra-2 gene (Fra-2), a fos-family member, can compete with Fos protein for participation in activating protein-1 (AP-1) transcription factor complexes and each protein can contribute different transactivational consequences to an AP-1 complex. To date, there is limited characterization of fra-2 mRNA expression in the rat forebrain. We examined basal and restraint-induc...
متن کاملESTRAINT-INDUCED fra-2 AND c-fos EXPRESSION IN THE RAT OREBRAIN: RELATIONSHIP TO STRESS DURATION
bstract—The protein product of the fra-2 gene (Fra-2), a os-family member, can compete with Fos protein for particpation in activating protein-1 (AP-1) transcription factor omplexes and each protein can contribute different transctivational consequences to an AP-1 complex. To date, here is limited characterization of fra-2 mRNA expression n the rat forebrain. We examined basal and restraint-inu...
متن کاملSelective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer
Tongue squamous cell carcinoma (TSCC) is most aggressive head and neck cancer often associated with HR-HPV infection. The role of AP-1 which is an essential regulator of HPV oncogene expression and tumorigenesis is not reported in tongue cancer. One hundred tongue tissue biopsies comprising precancer, cancer and adjacent controls including two tongue cancer cell lines were employed to study the...
متن کاملc-Fos Expression during Temporal Order Judgment in Mice
The neuronal mechanisms for ordering sensory signals in time still need to be clarified despite a long history of research. To address this issue, we recently developed a behavioral task of temporal order judgment in mice. In the present study, we examined the expression of c-Fos, a marker of neural activation, in mice just after they carried out the temporal order judgment task. The expression...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genes & Development
سال: 2000
ISSN: 0890-9369
DOI: 10.1101/gad.187900